Transforming growth factor-β and abdominal aortic aneurysms

Transforming growth factor β2 mutations and familial thoracic aortic aneurysms.

The Pathogenic Transforming Growth Factor-β Overdrive Hypothesis in Aortic Aneurysms and Dissections

Syndromic thoracic aortic aneurysms and dissections (TAADs) develop in patients with connective tissue disorders because of genetic mutations that affect structural components of the extracellular matrix and the cell contractile machinery. Early pathogenic hypotheses attributed the aortopathy to structural failure of the aortic tissue. Over 14 years ago, Neptune et al, Habashi et al, and Lindsa...

Transforming Growth Factor‐β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?

M arfan syndrome is a multisystem disorder, but its most devastating manifestations are aortic aneurysms and dissection. This syndrome results from mutations in FBN1, which encodes fibrillin-1, a microfibrillar protein that decorates the surface of elastin fibers. Over 100 known mutations in FBN1 cause Marfan syndrome, resulting in a wide variance of clinical presentations in affected individua...

Transforming growth factor-β

Dna2 was first characterized in yeast as an essential gene encoding a protein with both helicase and endonuclease activities involved in maturation of Okazaki fragments during DNA replication. Dna2 also plays a role in double-strand break (DSB) repair by homolo-gous recombination. The respective contributions of its replication and/or repair functions toward cell viability and resistance to gen...

Effect of Transforming Growth Factor-β (TGF-β) on proliferation of gastric epithelial cells in culture

Objective: Helicobacter pylori has a well-established role in the development of gastric cancer. In vitro studies reveal increased proliferation of the gastric mucosa in the presence of H. pylori infection. It has been also shown that production of some cytokines, such as interleukin-1 beta (IL-1b) is in...